Table of Contents
Outline
Free Radical theory of Aging
Energy utilization partitioning
Slide 4
Slide 5
What are the effects of oxidative stress?
Oxidative Stress mutants
Catalytic antioxidants tested in Sod2-/- mice, and in aging paradigms
Efficacy of EUK antioxidants in biology
Caenorhabditis elegans
Genetic inactivation of superoxide dismutase (SOD) in mice - phenotypes
Dilated cardiomyopathy as a result of endogenous mitochondrial oxidative stress
Mural thrombi in sod2 nullizygous heart
Massive accumulation of lipid in liver due to endogenous oxidative stress
Brain - Regional mitochondrial Aconitase activity in 9-10 day old Sod2-/- mice
Catalytic antioxidants tested in Sod2-/- mice, and in aging paradigms
Catalytic Antioxidant treatment of sod2 nullizygous mice
Slide 18
Survival curves - treated versus untreated
Spongiform encephalopathy in sod2 nullizygous mice
Mitochondrial ballooning in brain of sod2 nullizygous mice
GFAP staining of brain of sod2 nullizygous mice treated with MnTBAP
EUK-8 treatment rescues hepatic lipid build-up
Catalytic antioxidants tested in Sod2-/- mice
Rescue of spongiform encephalopathy in high dose EUK treated Sod2 mutant mice
Aconitase activity in 3 week old Sod2 -/- mouse brain - efficacy of EUK-8 versus MnTBAP
Pharmacogenomic and proteomic profiling of mitochondrial oxidative stress
Statistical analysis of microarrays
Ongoing studies
Slide 30
Summary
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