Ongoing studies
Validated approach in simple organism
Determining if effective antioxidant therapy will extend mean and maximum lifespan of mice
Determining if gene expression profiles of mitochondrial oxidative stress overlap with that of aging
Determining if proteomic profiles of mitochondrial oxidative stress overlap with aging
Determining if array of molecular targets rescued by effective antioxidant therapy are similar between acute mitochondrial oxidative stress and chronic oxidative stress
Determining if interventional approaches with efficacious drugs are effective in both prolonging lifespan and reversing age-related changes in mice