Event:

 
News

• Nobel laureate, Dr. Elizabeth Blackburn accepts the Paola S. Timiras Award for Aging Research presented by CREA

  Nobel laureate, Dr. Elizabeth Blackburn accepts the Paola S. Timiras Award for Aging Research from Dr. George Brooks and Steven A. Garan	Dr. Blackburn gives lecture on telomeres and their role in aging at CREA.	Dr. Blackburn photographed with CREA's chairman Dr. George Brooks, director of Bioinformatics Steven A. Garan and CREA's lab members

• CREA uses the Center for Research and Education in Aging Language (CREAL) to simulate glucose passage and absorption through the gastrointestinal tract and subsequent modulation of insulin and glucagon secretion in humans (LINK)

• CREA develops a language for describing biological systems from a macro to a molecular scale (LINK)

Leadership

• George A. Brooks,
  Professor in the Department of Integrative Biology,
  at the University of California, Berkeley,
  Chairman,
  Center for Research and Education on Aging (CREA)
  University of California, Berkeley

• Steven A. Garan,
  Researcher,
  Lawrence Berkeley National Laboratory, Berkeley,
  Director of Bioinformatics,
  Center for Research and Education on Aging (CREA)
  University of California, Berkeley

 

Research Funded by CREA An interactive quantitative temporal physiological model of glucose passage and absorption through the gastrointestinal tract and subsequent modulation of insulin and glucagon secretion in humans; Steven A. Garan, Shuzhang Sun, Hashroop K. Gurm, Alexander Chen, Anensshiya Govinthasamy, Kimberly D. Pham, Gizem Efe, Tiffany H. Chen, Shivam Sachaphimukh, Sheba Plamthottam, Benyam Goitom, Nabhojit Banerjee, Randall White, Behnaz Ahmed, Aida Sarcon, Warren Freitag, Luc J. C. van Loon and George A. Brooks FASEB Journal. 2013;27:1213.2. CREAL: A language for describing biological systems from a macro to a molecular scale; S.A. Garan, A. Sarcon, A. Chen, E. Lu, H.K. Gurm, S. Gunther, B.C. Zheng, J. Zhu, N. Banerjee, A. Govinthasamy, R. Neumann, W. Freitag, G.A. Brooks FASEB Journal. 2012; 26:717. Visualizing hypothalamic interactions with anatomic, mechanistic and pathway hierarchies that regulate the aging process; S.A. Garan, W. Freitag, M. Siddiqui, A. Siddiqui Experimental Gerontology, Volume 46, Issues 2-3, February-March 2011, Pages 209-210 Estrogen receptor-alpha immunoreactivity in the arcuate hypothalamus of young and middle-aged female mice; Yaghmaie F, Saeed O, Garan SA, Voelker MA, Sternberg H, Timiras PS; Neuro Endocrinol Lett. 2010 Feb 16;31(1):15. An automated method of performing neuropsychological tests in studying gustatory reward circuitry; A.M. Gouw, S.A. Garan, W. Freitag, J.D. Woolley; Rejuvenation Research. September 2009: page S-31 The plasticity of neural cell reprogramming: Role of growth factors in inducing neuroglia to neuron and to neural precursor cell; A.M. Gouw, K. Mahuron, S. Manandhar, A. Tin, S.A. Garan, P. Hakimi, P.S. Timiras; Experimental Gerontology, Volume 44, Issues 1-2, January-February 2009, Page 129 Shortest path algorithms combined with natural language parsing, map pathways involved in neuroendocrine aging; S.A. Garan, W. Freitag, A.M. Gouw, B. Rizvi, S. Prashad, V. Csapo; Experimental Gerontology, Volume 44, Issues 1-2, January-February 2009, Page 129 The Potential Role of Epidermal Growth Factor (EGF) and Curcumin in Transforming Neuroglia into Neurons; AM Gouw, H Panchal, K Mahuron, H Wadhwani, S Manandhar, SA Garan, A Tin, PS Timiras; Endocrine Society's 90th Conference Proceedings, June 2008, Page 364 A computational systems biology approach to neuroendocrine aging: Initial results; S.A. Garan, W. Freitag, V. Csapo, P. Chrysler, B. Rizvi and N. Shewaramani; Experimental Gerontology, Volume 42, Issues 1-2 , January-February 2007, Page 142 Age-dependent loss of insulin-like growth factor-1 receptor immunoreactive cells in the supraoptic hypothalamus is reduced in calorically restricted mice; Yaghmaie F, Saeed O, Garan SA, Voelker MA, Gouw AM, Freitag W, Sternberg H, Timiras PS.; Neurology & Neurosurgery, Para. 488, Page 99, Sec. 8, Vol 152.2, 2007 Novel methods in computer-assisted tissue analysis: Customized regional targeting of both cytoplasmic and nuclear-stained tissue; S.A. Garan, F. Yaghmaie, O. Saeed, A.M. Gouw, W. Freitag, M.A. Voelker, P. Jafar, J. Kaur and S. Nijjar; Experimental Gerontology, Volume 42, Issues 1-2, January-February 2007, Pages 141-142

Tracking changes in hypothalamic IGF-1 sensitivity with aging and caloric restriction; F. Yaghmaie, O. Saeed, S.A. Garan, A.M. Gouw, P. Jafar, J. Kaur, S. Nijjar, P.S. Timiras, H. Sternberg and M.A. Voelker; Experimental Gerontology, Volume 42, Issues 1-2 , January-February 2007, Pages 11-12. Insulin-like growth factor-1 receptor immunoreactive cells are selectively maintained in the paraventricular hypothalamus of calorically restricted mice; Saeed O, Yaghmaie F, Garan SA, Gouw AM, Voelker MA, Sternberg H, Timiras PS.; Int J Dev Neurosci. 2007 Feb;25(1):23-8 Age-dependent loss of insulin-like growth factor-1 receptor immunoreactive cells in the supraoptic hypothalamus is reduced in calorically restricted mice; Yaghmaie F, Saeed O, Garan SA, Voelker MA, Gouw AM, Freitag W, Sternberg H, Timiras PS.; Int J Dev Neurosci. 2006 Nov;24(7):431-6. A study of insulin-like growth factor-I receptor immunoreactivity in the supraoptic nucleus of young and old female B6D2F1 mice; Farzin Yaghmaie, Omar Saeed, Steven A. Garan, Arvin M. Gouw, Tien Tran, Jacqueline Ho, Liu Y. Zhao, Mark A. Voelker and Paola S. Timiras; FASEB Journal, April 2006, 357.5 Caloric restriction reduces cell loss and maintains estrogen receptor-alpha immunoreactivity in the pre-optic hypothalamus of female B6D2F1 mice; Yaghmaie F, Saeed O, Garan SA, Freitag W, Timiras PS, Sternberg H; Neuro Endocrinol Lett. 2005 Jun;26(3):197-203. A survey of estrogen receptor-alpha immunoreactivity in the hypothalamus of young, old, and old-calorie restricted female B6D2F1 mice; F. Yaghmaie, S.A. Garan, O. Saeed, W. Freitag, P.S. Timiras, H. Sternberg, M. Voelker; Experimental Gerontology, Volume 39, Issues 11-12, November-December 2004, Page 1771 Towards a self-learning, self-assembling systemic map of neuroendocrine aging; S.A. Garan, W. Freitag, F. Yaghmaie, B. Oster, P. Chrysler, R. Bacinello, K. Honeyford, P. Yaghmaie, M., Voelker, P.S. Timiras; Experimental Gerontology, Volume 39, Issues 11-12, November-December 2004, Page 1767 Phenomics: a new direction for the study of neuroendocrine aging; S.A. Garan, W. Freitag, F. Yaghmaie, B. Oster, P.S. Timiras; Experimental Gerontology, Volume 38 (2003), Issues 1-2, Page 218 A comparison of estrogen receptor-alpha immunoreactivity in the arcuate hypothalamus of young and middle-aged C57BL6 female mice; Yaghmaie F, Garan SA, Massaro M, Timiras PS; Experimental Gerontology, Volume 38 (2003), Issues 1-2, Page 220 Creating Three-Dimensional Neuronal Maps of the Mouse Hypothalamus Using an Automated Imaging Microscope System; Garan SA, Neudorf J, Tonkin J, McCook LR, Timiras PS.; Experimental Gerontology, Volume 35 numbers 9-10, December 2000, page 1421 Automated Imaging Microscope System; Jason Neudorf and Steven A. Garan; Linux Journal 2000, Issue 70, Februrary, Page 32-35

Physiology   Systems Biology   Neurology   Neuroendocrinology   Genetics   Molecular Biology

 
 
 
 
 
 
  New Concepts in the study of Aging  
 
  

Dr. Paola S. Timiras  talks about the study of aging and how new concepts and techologies are helping to shed light on the aging process. She says that many scientists have changed their views on aging, from one of resignation to that of a willingness to find ways of modifying the aging process and extending the human health span.

Dr. Paola S. Timiras